On 11th Nov. 2016, CFDA released a notice to adopt In Vitro 3T3 Neutral Red Uptake Phototoxicity Assay (In Vitro 3T3 NRU PT) on cosmetic ingredients. This method is added to the Chapter VI of Technical Safety Standard of Cosmetics 2015. As we know, In Vitro 3T3 NRU PT has been consulted in public since 2012 and final accepted after 4 years. Definitely, it represents a step forward toward alternative methods in cosmetics in China.
In Vitro 3T3 NRU PT was developed and validated in a joint EU/COLIPA project from 1992-1997. In April 2004, In Vitro 3T3 NRU PT was finalized and adopted as OECD No. 432 for the assessment of chemical substances by in vitro approach. Chinese version of 3T3 NRU PT is compiled based on OECD No. 432. 2004 and Annex VI to Consolidated Version of Directive 67/548/EEC. This method is recommended to be used in the evaluation of potential phototoxicity of cosmetic ingredients.
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